Ongoing Studies
Car Seat Tolerance Screening in Newborns: Epidemiology and Outcomes
PI Skye McLaurin-Jiang and her co-investigators are working on a retrospective cohort study around CSTS Screening. The aims of the study are: 1) describe which infants undergo a pre-discharge CSTS, 2) describe the epidemiology of CSTS failure, and 3) determine the relative risk of adverse outcomes in infants who failed an initial CSTS.
COVID Case Study
PI Jayme Congdon is collecting cases of newborns with COVID-19 positive mothers across the BORN network.
COVID Variations
Elena Aragona has created a cross-sectional survey to examine variations in the evaluation, routine care and discharge planning of mothers and infants for COVID-19 in Well Newborn Units in the BORN network.
Umbilical Nonseverance
The goal of Kimberly K. Monroe’s study is to examine and describe the practice of umbilical nonseverance along with related incidences of infection.
Vaccine Preferences
Jake Lohr’s study into vaccine preferences aims to determine when first-time parents in the immediate postpartum period developed their vaccine preferences: before, after or during pregnancy. The secondary aim is to determine what co-variables (demographic and otherwise) contribute to the timing of parents’ development of vaccine preferences. Characterize the external factors (e.g, individuals, information sources) that contribute to vaccine preference development.
Completed Studies
Management of Newborns with Lumbosacral Findings
This cross-sectional study of management choices made by practitioners who see newborns in a regular newborn nursury setting aims to see how much inter-observer agreement exists for management of various neonatal lumbosacral findings.
Vitamin K Refusal
As a follow-up to PI Jaspreet Loyal's, Yale University, earlier project surveying BORN nursery directors perceptions of Vitamin K refusals at their institutions, the aims of the current study are to 1) report the number of infants discharged from newborn nurseries in the BORN network who did not receive IM vitamin K and 2) describe the epidemiology of infants not receiving IM vitamin K and their mothers.
Hypoglycemia
In this BORN study, Sudha Rani Narasimhan aims to describe and analyze the practice variations related to routine maternity and newborn care, breastfeeding practices, diagnosis and treatment of hypoglycemia.
Breastfeeding Study
Laura Kair’s prospective cohort study aimed to identify hospital practices associated with any and exclusive breastfeeding at 3 months of age among infants born at 34-36 6/7 weeks’ gestation who are admitted to the well-baby nursery.
Newborn Bathing
Ann Kellam’s study surveyed variations on standardized procedures related to the bathing of newborns across multiple BORN locations.
The Utility of Transcutaneous Bilirubin Measurement
Jim Taylor, University of Washington, served as PI for the first study conducted by the BORN network. The specific aims of the study were to: 1) Describe the distribution of TcB values in term and late preterm newborns measured in diverse settings by developing a TcB nomogram based on the data collected (BORN TcB nomogram) 2) Identify test thresholds for TcB percentiles that maximize the specificity of the screening tool while maintaining sensitivity near 100% for identification of infants with significantly elevated TSB and 3) Identify systematic sources of error in TcB measurements.
BORN Delphi Study
The objective of this study led by PI Elizabeth Simpson, University of Missouri, was to develop a consensus-based, prioritized agenda for well newborn care. A two-round modified Delphi survey of BORN members was conducted. The highest rated research questions of importance to BORN clinicians were: 1) At what weight-loss percentage is it medically necessary to formula supplement a breastfeeding infant? 2) What is the optimal management of infants with neonatal abstinence syndrome? 3) How and when should we initiate a workup for sepsis, and how should these newborns be managed?
Variation in Care of Opioid-Exposed Newborns: a BORN survey
BORN member hospitals were surveyed to identify practice variations for newborns with in-utero chronic opioid exposure. Identification of variation is the first step toward establishing best practice standards to improve care for this rapidly growing population. Deb Bogen from University of Pittsburgh, was PI for this survey.
Practice Variation in Evaluation of Term Infants at Risk for Early-Onset Sepsis
PIs Sagori Mukhopadhyay and Karen Puopolo from UPenn surveyed BORN nursery directors to determine variation in the management of newborns at risk for EOS.
